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Friday, 10 December 2021
Wednesday, 3 October 2018
Pharmceutical Errors
Pharmceutical Errors are different from Medic ok p6 y yal Errors.
.
Manufacturing Errors
Compounding Errors
Compounding Errors
Dispensing Error
Storage Errors
Clerical errors
Inventory errors
computer entry
Inventory errors
computer entry
Data entry in sheet errors
Pharmceutical Calculation Errors
Pharmceutical Calculation Errors
Pharmaceutical Formulation Errors (Research & Development Errors)
Pharmaceutical Analysis Errors
Method of administration Errors
Drug Dose Titration Errors
Adverse Drug Reaction Reporting Errors (Pharmacovigilance Errors)
Drug Drug Interaction Reporting Errors
Ward Round Errors
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pharmaceutical,
thoughts
Friday, 3 August 2018
NUTRACEUTICALS
A Nutraceutical is a pharmaceutical-grade and standardized nutrient.[1] In the US, "nutraceuticals" do not exist as a regulatory category; they are regulated as dietary supplements and food additives by the FDA under the authority of the Federal Food, Drug, and Cosmetic Act.
Regulation[edit]
Nutraceuticals are treated differently in different jurisdictions.
Canada[edit]
Under Canadian law, a nutraceutical can either be marketed as a food or as a drug; the terms "nutraceutical" and "functional food" have no legal distinction,[3] referring to "a product isolated or purified from foods that is generally sold in medicinal forms not usually associated with food [and] is demonstrated to have a physiological benefit or provide protection against chronic disease."
United States[edit]
The term "nutraceutical" is not defined by US law.[4] Depending on its ingredients and the claims with which it is marketed, a product is regulated as a drug, dietary supplement, food ingredient, or food.[5][6]
International sources[edit]
In the global market, there are significant product quality issues.[7] Nutraceuticals from the international market may claim to use organic or exotic ingredients, yet the lack of regulation may compromise the safety and effectiveness of products. Companies looking to create a wide profit margin may create unregulated products overseas with low-quality or ineffective ingredients.
Market[edit]
A market research report produced in 2012 projected that the worldwide nutraceuticals market would reach US$250 billion by 2018,[8] defining that market as "Dietary Supplements (Vitamins, Minerals, Herbals, Non-Herbals, & Others), and Functional Foods & Beverages"[9]
Classification of nutraceuticals[edit]
Nutraceuticals are products derived from food sources that are purported to provide extra health benefits, in addition to the basic nutritional value found in foods. Depending on the jurisdiction, products may claim to prevent chronic diseases, improve health, delay the aging process, increase life expectancy, or support the structure or function of the body.[10]
Dietary supplements[edit]
In the United States, the Dietary Supplement Health and Education Act (DSHEA) of 1994 defined the term: “A dietary supplement is a product taken by mouth that contains a "dietary ingredient" intended to supplement the diet. The "dietary ingredients" in these products may include: vitamins, minerals, herbs or other botanicals, amino acids, and substances such as enzymes, organ tissues, glandulars, and metabolites. Dietary supplements can also be extracts or concentrates, and may be found in many forms such as tablets, capsules, softgels, gelcaps, liquids, or powders.”[11]
Dietary supplements do not have to be approved by the U.S. Food and Drug Administration (FDA) before marketing, but companies must register their manufacturing facilities with the FDA and follow current good manufacturing practices (cGMPs). With a few well-defined exceptions, dietary supplements may only be marketed to support the structure or function of the body, and may not claim to treat a disease or condition, and must include a label that says: “These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.” The exceptions are when the FDA has reviewed and approved a health claim. In those situations the FDA also stipulates the exact wording allowed.
Functional foods[edit]
Functional foods are fortified or enriched during processing and then marketed as providing some benefit to consumers. Sometimes, additional complementary nutrients are added, such as vitamin D to milk.
Health Canada defines functional foods as “ordinary food that has components or ingredients added to give it a specific medical or physiologicalbenefit, other than a purely nutritional effect.”[12] In Japan, all functional foods must meet three established requirements: foods should be (1) present in their naturally occurring form, rather than a capsule, tablet, or powder; (2) consumed in the diet as often as daily; and (3) should regulate a biological process in hopes of preventing or controlling disease.[13]
History[edit]
The word "nutraceutical" is a portmanteau of the words "nutrition" and "pharmaceutical", was coined in 1989 by Stephen L. DeFelice, founder and chairman of the Foundation of Innovation Medicine.[14] Indians, Egyptians, Chinese, and Sumerians are just a few civilizations that have used food as medicine.[15] “Let food be thy medicine.” is a common misquotation [16] attributed to Hippocrates, who is considered by some to be the father of Western medicine.
The modern nutraceutical market began to develop in Japan during the 1980s. In contrast to the natural herbs and spices used as folk medicine for centuries throughout Asia, the nutraceutical industry has grown alongside the expansion and exploration of modern technology.[
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NUTRACEUTICALS
Tuesday, 31 July 2018
What is pharmaceutical biotechnology definition?
Pharmaceutical biotechnology is a relatively new and growing field in which the principles of biotechnology are applied to the development of drugs. A majority of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines
Biotechnology & Pharmaceutical Companies
While biotechnology and pharmaceutical companies both produce medicine,biotechnology companies' drugs have a biological basis, while those of pharmaceutical companies have a chemical basis. Biotechnology companiesuse live organisms or their products, such as bacteria or enzymes, to manufacture their medicines.
A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.
The primary difference between biopharmaceuticals and traditionalpharmaceuticals is the method by which the drugs are produced: The former are manufactured in living organisms such as bacteria, yeast and mammalian cells, whereas the latter are manufactured through a series of chemical synthesis.
A biopharmaceutical, also known as a biologic(al) medical product, biological, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources.
The primary difference between biopharmaceuticals and traditionalpharmaceuticals is the method by which the drugs are produced: The former are manufactured in living organisms such as bacteria, yeast and mammalian cells, whereas the latter are manufactured through a series of chemical synthesis.
Saturday, 7 July 2018
Relation between pharma and biotech
Relation between pharma and biotech
Unlike in other countries, the difference between biotechnology and pharmaceuticals remains fairly defined in India, with biotech a much smaller part of the economy. India accounted for 2% of the $41 billion global biotech market and in 2003 was ranked 3rd in the Asia-Pacific region and 13th in the world in number of biotech. In 2004-5, the Indian biotech industry saw its revenues grow 37% to $1.1 billion. The Indian biotech market is dominated by bio pharmaceuticals; 76% of 2004–5 revenues came from bio-pharmaceuticals, which saw 30% growth last year. Of the revenues from bio-pharmaceuticals, vaccines led the way, comprising 47% of sales. Biologics and large-molecule drugs tend to be more expensive than small-molecule drugs, and India hopes to sweep the market in bio-generics and contract manufacturing as drugs go off patent and Indian companies upgrade their manufacturing capabilities.[30]
Most companies in the biotech sector are extremely small, with only two firms breaking 100 million dollars in revenues. At last count there were 265 firms registered in India, over 92% of which were incorporated in the last five years. The newness of the companies explains the industry’s high consolidation in both physical and financial terms. Almost 30% of all biotech are in or around Bangalore, and the top ten companies capture 47% of the market. The top five companies were homegrown; Indian firms account for 72% of the bio-pharma sector and 52% of the industry as a whole.[4,46] The Association of Biotechnology-Led Enterprises (ABLE) is aiming to grow the industry to $5 billion in revenues generated by 1 million employees by 2009, and data from the Confederation of Indian Industry (CII) seem to suggest that it is possible.[31]
Comparison with the United States
Government support[edit]The Indian biotech sector parallels that of the US in many ways. Both are filled with small start-ups while the majority of the market is controlled by a few powerful companies. Both are dependent upon government grants and venture capitalists for funding because neither will be commercially viable for years. Pharmaceutical companies in both countries see growth potential in biotechnology and have either invested in existing start-ups or ventured into the field themselves.[3]
The Indian government established the Department of Biotechnology in 1986 under the Ministry of Science and Technology. Since then, there have been a number of dispensations offered by both the central government and various states to encourage the growth of the industry. India’s science minister launched a program that provides tax incentives and grants for biotech start-ups and firms seeking to expand and establishes the Biotechnology Parks Society of India to support ten biotech parks by 2010. Previously limited to rodents, animal testing was expanded to include large animals as part of the minister’s initiative. States have started to vie with one another for biotech business, and they are offering such goodies as exemption from VAT and other fees, financial assistance with patents and subsidies on everything ranging from investment to land to utilities.[32]
The biotechnology sector faces some major challenges in its quest for growth. Chief among them is a lack of funding, particularly for firms that are just starting out. The most likely sources of funds are government grants and venture capital, which is a relatively young industry in India. Government grants are difficult to secure, and due to the expensive and uncertain nature of biotech research, venture capitalists are reluctant to invest in firms that have not yet developed a commercially viable product.[33]
The government has addressed the problem of educated but unqualified candidates in its Draft National Biotech Development Strategy. This plan included a proposal to create a National Task Force that will work with the biotech industry to revise the curriculum for undergraduate and graduate study in life sciences and biotechnology. The government’s strategy also stated intentions to increase the number of PhD Fellowships awarded by the Department of Biotechnology to 200 per year. These human resources will be further leveraged with a "Bio-Edu-Grid" that will knit together the resources of the academic and scientific industrial communities, much as they are in the US.[33]
Foreign investment
Sunday, 17 June 2018
Bioengineering
Biological engineering or bio-engineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products.[1] Biological engineering employs knowledge and expertise from a number of pure and applied sciences,[2]such as mass and heat transfer, kinetics, biocatalysts, biomechanics, bioinformatics, separation and purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science. It is used in the design of medical devices, diagnostic equipment, biocompatible materials, renewable bioenergy, ecological engineering, agricultural engineering, and other areas that improve the living standards of societies.
In general, biological engineers attempt to either mimic biological systems to create products or modify and control biological systems so that they can replace, augment, sustain, or predict chemical and mechanical processes.[3] Bioengineers can apply their expertise to other applications of engineering and biotechnology, including genetic modification of plants and microorganisms, bioprocess engineering, and biocatalysis.
History[edit]
Biological engineering is a science-based discipline founded upon the biological sciences in the same way that chemical engineering, electrical engineering, and mechanical engineering[4] can be based upon chemistry, electricity and magnetism, and classical mechanics, respectively.[5]
Before WWII, biological engineering had just begun being recognized as a branch of engineering, and was a very new concept to people. Post-WWII, it started to grow more rapidly, partially due to the term "bioengineering" being coined by British scientist and broadcaster Heinz Wolff in 1954 at the National Institute for Medical Research. Wolff graduated that same year and became the director of the Division of Biological Engineering at the university. This was the first time Bioengineering was recognized as its own branch at a university. Electrical engineering is considered to pioneer this engineering sector due to its work with medical devices and machinery during this time[6].When engineers and life scientists started working together, they recognized the problem that the engineers didn't know enough about the actual biology behind their work. To resolve this problem, engineers who wanted to get into biological engineering devoted more of their time and studies to the details and processes that go into fields such as biology, psychology, and medicine[7].The term biological engineering may also be applied to environmental modifications such as surface soil protection, slope stabilization, watercourse and shoreline protection, windbreaks, vegetation barriers including noise barriers and visual screens, and the ecological enhancement of an area. Because other engineering disciplines also address living organisms, the term biological engineering can be applied more broadly to include agricultural engineering.
The first biological engineering program was created at University of California, San Diego in 1966, making it the first biological engineering curriculum in the United States.[8] More recent programs have been launched at MIT[9] and Utah State University.[10] Many old agricultural engineering departments in universities over the world have re-branded themselves as agricultural and biological engineering or agricultural and biosystems engineering, due to biological engineering as a whole being a rapidly developing field with fluid categorization. According to Professor Doug Lauffenburger of MIT,[9][11] biological engineering has a broad base which applies engineering principles to an enormous range of size and complexities of systems. These systems range from the molecular level (molecular biology, biochemistry, microbiology, pharmacology, protein chemistry, cytology, immunology, neurobiology and neuroscience) to cellular and tissue-based systems (including devices and sensors), to whole macroscopic organisms (plants, animals), and can even range up to entire ecosystems.
Education[edit]
The average length of study is three to five years, and the completed degree is signified as a bachelor of engineering (B.S. in engineering). Fundamental courses include thermodynamics, fluid and mechanical dynamics, kinetics, electronics, and materials properties.[12][13]
Sub-disciplines[edit]
Depending on the institution and particular definitional boundaries employed, some major branches of bioengineering may be categorized as (note these may overlap):
- Biomedical Engineering: application of engineering principles and design concepts to medicine and biology for healthcare purposes[14]
- Biochemical Engineering: fermentation engineering, application of engineering principles to microscopic biological systems that are used to create new products by synthesis, including the production of protein from suitable raw materials[14]
- Biological Systems Engineering: application of engineering principles and design concepts to agriculture, food sciences, and ecosystems.[4]
- Bioprocess Engineering: develops technology to monitor the conditions of the where the process of making pharmaceuticals takes place[14], (Ex: bioprocess design, biocatalysis, bioseparation, bioinformatics, bioenergy)
- Environmental Health Engineering: application of engineering principles to the control of the environment for the health, comfort, and safety of human beings. It includes the field of life-support systems for the exploration of outer space and the ocean[14]
- Human-Factors Engineering: application of engineering, physiology, and psychology to the optimization of the human–machine relationship[14]
- Biotechnology: the use of living systems and organisms to develop or make products[15]. (Ex: pharmaceuticals)[14]
- Biomimetics: the imitation of models, systems, and elements of nature for the purpose of solving complex human problems. (Ex: velcro, designed after George de Mestral noticed how easily burs stuck to a dog's hair)[16]\
- Bioelectrical Engineering:
- Biomechanical Engineering:
- Bionics: an integration of Biomedical, focused more on the robotics and assisted technologies. (Ex: prosthetics)[14]
- Bioprinting: utilizing biomaterials to print organs and new tissues[17]
- Biorobotics: (Ex: prosthetics)
- Systems Biology: The study of biological systems.
Organizations
Organizations[edit]
- Accreditation Board for Engineering and Technology (ABET),[18] the U.S.-based accreditation board for engineering B.S. programs, makes a distinction between biomedical engineering and biological engineering, though there is much overlap (see above).
- American Institute for Medical and Biological Engineering (AIMBE) is made up of 1,500 members. Their main goal is to educate the public about the value biological engineering has in our world, as well as invest in research and other programs to advance the field. They give out awards to those dedicated to innovation in the field, and awards of achievement in the field. (They do not have a direct contribution TO biological engineering, they more recognize those who do and encourage the public to continue that forward movement)[19]
- Institute of Biological Engineering (IBE) is a non-profit organization, they run on donations alone. They aim to encourage the public to learn and to continue advancements in biological engineering. (Like AIMBE, they don't do research directly, they do however offer scholarships to students who show promise in the field)[20].
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